免疫佐剂，是一类可以增强抗原免疫原性的免疫调节分子、化合物或大分子复合物。大多数佐剂可以通过启动先天免疫系统来辅助抗原应答。先天免疫系统通过模式识别受体（pattern recognition receptor，PRR）来感知各种微生物表达的病原体相关分子模式（PAMPs）的存在，激活对病原体的先天性免疫信号通路并调节适应性免疫应答。添加天然或人工合成的佐剂分子有助于恢复或改进纯化抗原的免疫原性，调节免疫应答类型，在现代疫苗学研究中具有重要意义。含 CpG 序列的寡脱氧核苷酸（oligonucleotide，ODN）可模拟哺乳动物免疫系统的“危险信号”，参与机体免疫应答的调节，增强疫苗的免疫原性。
艾美捷科技为您推荐Enzo精品低内毒素的CpG ODN，寡聚脱氧核苷酸全家族产品。
| 货号 | 名称 | 规格 | 说明 |
| ALX-746-001-C100 | ODN 1668 (TLRGRADE®) (synthetic) | 100ug | B型。小鼠TLR9的特异性配体 |
| ALX-746-051-M001 | ODN 1668 (TLRGRADE®) (synthetic) (BULK) | 1mg | B型。小鼠TLR9的特异性配体 |
| ALX-746-200-T100 | ODN 1720 (TLRGRADE®) (synthetic) (Control) | 100tests | ODN 1668的阴性对照 |
| ALX-746-002-C100 | ODN 1826 (TLRGRADE®) (synthetic) | 100ug | B型。小鼠TLR9的特异性配体 |
| ALX-746-052-M001 | ODN 1826 (TLRGRADE®) (synthetic) (BULK) | 1mg | B型。小鼠TLR9的特异性配体 |
| ALX-746-201-C100 | ODN 1982 (TLRGRADE®) (synthetic) (Control) | 100ug | ODN 1826的阴性对照 |
| ALX-746-003-C100 | ODN 1585 (TLRGRADE®) (synthetic) | 100ug | A型。小鼠TLR9的特异性配体 |
| ALX-746-053-M001 | ODN 1585 (TLRGRADE®) (synthetic) (BULK) | 1mg | A型。小鼠TLR9的特异性配体 |
| ALX-746-006-C100 | ODN 2006 (TLRGRADE®) (synthetic) | 100ug | B型。人和小鼠TLR9的特异性配体 |
| ALX-746-056-M001 | ODN 2006 (TLRGRADE®) (synthetic) (BULK) | 1mg | B型。人和小鼠TLR9的特异性配体 |
| ALX-746-206-C100 | ODN 2137 (TLRGRADE®) (synthetic) (Control) | 100ug | ODN 2006的阴性对照 |
| ALX-746-005-C100 | ODN 2216 (TLRGRADE®) (synthetic) | 100ug | A型。人TLR9的特异性配体 |
| ALX-746-055-M001 | ODN 2216 (TLRGRADE®) (synthetic) (BULK) | 1mg | A型。人TLR9的特异性配体 |
| ALX-746-020-C100 | ODN 2395 (TLRGRADE®) (synthetic) | 100ug | C型。人和小鼠TLR9的特异性配体 |
| ALX-746-070-M001 | ODN 2395 (TLRGRADE®) (synthetic) (BULK) | 1mg | C型。人和小鼠TLR9的特异性配体 |
| ALX-746-250-C200 | iODN 2088 (class I) (endotoxin-free) (synthetic) | 200ug | 抑制性iODN，可能影响TLR7与TLR8通路 |
| ALX-746-251-T050 | iODN (ttaggg)4 (class II) (endotoxin-free) (synthetic) | 50tests | 抑制性iODN，基于ODN A151，抑制STAT通路 |
| ALX-505-007-L010 | ddWater (endotoxin-free) (sterile) | 10ml | 内毒素<0.0002EU/mg |
| ALX-505-007-L010 | PBS (endotoxin-free) (sterile) | 10ml | 内毒素<0.0002EU/mg |
* 更多CpG ODN，寡聚脱氧核苷酸产品，欢迎垂询艾美捷。
* 上述产品，仅供科研使用，不得用于医疗.
【CpG ODN，寡聚脱氧核苷酸全家族产品优势】
1、无内毒素水，ddWater
2、除对照产品外，产品内均已提供阴性对照
3、无菌，冻干粉，内毒素<0.002EU/µg
4、BULK：可用于体内实验
【Cell文章鉴赏】
IF=66.8, 《Systematic discovery of TLR signaling components delineates viral-sensing circuits 》,Cell
【Enzo精品低内毒素的CpG ODN，寡聚脱氧核苷酸，更多发表文章】
- Ban, T., Kikuchi, M., Sato, G.R. et al. Genetic and chemical inhibition of IRF5 suppresses pre-existing mouse lupus-like disease. Nat Commun12, 4379 (2021).
- Contact-dependent inhibition of HIV-1 replication in ex vivo human tonsil cultures by polymorphonuclear neutrophils: T. Reif, et al.; Cell Rep. Med. 2, 100317 (2021)
- Homeostatic and Pathogenic Roles of GM3 Ganglioside Molecular Species in TLR4 Signaling in Obesity: H. Kanoh, et al.; EMBO J. 39, e101732 (2020)
- Murakami, Yuki, et al. "Increased regulatory B cells are involved in immune evasion in patients with gastric cancer." Scientific reports 9.1 (2019): 1-9.
- Maatouk, L., Compagnion, AC., Sauvage, MA.Cd. et al. TLR9 activation via microglial glucocorticoid receptors contributes to degeneration of midbrain dopamine neurons. Nat Commun9, 2450 (2018).
- Okamura, T., Sumitomo, S., Morita, K. et al. TGF-β3-expressing CD4+CD25−LAG3+ regulatory T cells control humoral immune responses. Nat Commun6, 6329 (2015).
- Chevrier, Nicolas et al. "Systematic discovery of TLR signaling components delineates viral-sensing circuits". Cell vol .147,4 (2011): 853-67.
- Larson, S. R., et al. "Ly6C+ monocyte efferocytosis and cross-presentation of cell-associated antigens." Cell Death & Differentiation 23.6 (2016): 997-1003.
- Jia, Xianxian, et al. "CCK 8 negatively regulates the TLR 9‐induced activation of human peripheral blood p DC s by targeting TRAF 6 signaling." European Journal of Immunology 44.2 (2014): 489-499.
- TLR9-signaling is required for turning retinoic acid into a potent stimulator of RP105 (CD180)-mediated proliferation and IgG synthesis in human memory B cells: A. Eriksen, et al.; Cell. Immunol. 279, 87 (2012)
- Activation of murine macrophages via TLR2 and TLR4 is negatively regulated by a Lyn/PI3K module and promoted by SHIP1: S. Keck, et al.; J. Immunol. 184, 5809 (2010)
- Cutting edge: the mechanism of invariant NKT cell responses to viral danger signals: A.J. Tyznik, et al.; J. Immunol. 181, 4452 (2008)
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来源：Enzo超全低内毒素，CpG ODN，寡聚脱氧核苷酸家族产品
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