Highly concentrated phospholipid dispersions of vesicular morphology, Vesicular phospholipid Gels (VPGs) are of importance for sustained release of drugs upon implantation, or, upon transfer into SUV-dispersions, for drug delivery upon i.v. injection. Here the formation of homogeneous lipid and lipid/drug-blends is described as well as the preparation of VPGs by high-pressure homogenization, along with remote loading via “passive loading”.
