Transmembrane Signaling by G Protein-Coupled Receptors

G protein-coupled receptors (GPCRs) make up the largest and most diverse family of membrane receptors in the human genome, relaying information about the presence of diverse extracellular stimuli to the cell interior. All known GPCRs share a common architecture of seven membrane-spanning helices connected by intra- and extracellular loops. Most GPCR-mediated cellular responses result from the receptor acting as a ligand-activated guanine nucleotide exchange factor for heterotrimeric guanine nucleotide-binding (G) proteins whose dissociated subunits activate effector enzymes or ion chan-nels. GPCR signaling is subject to extensive negative regulation through receptor desensitization, sequestration, and down regulation, termination of G protein activation by GTPase-activation proteins, and enzymatic degradation of second messengers. Addi-tional protein—protein interactions positively modulate GPCR signaling by influencing ligand-binding affinity and specificity, coupling between receptors, G proteins and effectors, or targeting to specific subcellular locations. These include the formation of GPCR homo- and heterodimers, the interaction of GPCRs with receptor activity-modi-fying proteins, and the binding of various scaffolding proteins to intracellular receptor domains. In some cases, these processes appear to generate signals in conjunction with, or even independent of, G protein activation.

内容来源:生物资料网,如果侵权麻烦联系网站工作人员删除!

艾美捷科技优势代理品牌

发表评论

:?: :razz: :sad: :evil: :!: :smile: :oops: :grin: :eek: :shock: :???: :cool: :lol: :mad: :twisted: :roll: :wink: :idea: :arrow: :neutral: :cry: :mrgreen: