Therapeutic Inhibition of Angiogenesis

The idea of antiangiogenesis as a therapeutic strategy has been around for several decades (1 ). Vigorously pursued as a novel anticancer strategy (reviewed in (2 –6 ), it is now widely considered to be a promising approach to the treatment of a range of pathologies of which uncontrolled vascular proliferation is a component (seeTable 1 ). To date, therapeutic benefit has been achieved with antiangiogenic therapy in the treatment of life-threatening infantile hemangioma, pulmonary hemangiomatosis, and in the treatment of some vascular tumors (7 ,8 ). Table 1Table 1

Pathologies Likely to Benefit from Therapeutic Intervention in Angiogenesis

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