Principles of Membrane Electroporation and Transport of Macromolecules

The phenomenon of membrane electroporation (ME) methodologically comprises an electric technique to render lipid and lipid-protein membranes porous and permeable, transiently and reversibly, by electric voltage pulses. It is of great practical importance that theprimarystructural changes induced by ME, condition the electroporated membrane for a variety ofsecondaryprocesses, such as, for instance, the permeation of otherwise impermeable substances.

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