Chronic myelogenous leukemia (CML), a clonal myeloproliferative disorder in adults, and some pediatric and adult acute lymphoblastic eukemias (ALLs) are characterized by the presence of a Philadelphia chromosome, t(9;22)(q34;q11) (1 ). In this chromosomal translocation, exons from a major breakpoint cluster region (M-bcr), located on chromosome 22q11, are joined to the c-ablprotooncogene, located on chromosome 9q34. When this chromosomal translocation occurs in a hematopoietic stem cell, the resulting BCR/ablfusion protein has increased tyrosine kinase activity and a transforming capacity that is critical to the pathogenesis of these leukemic disorders.
