PBL Assay Science 多文献IFN-α全亚型ELISA试剂盒

IFN-α（Interferon-alpha，IFN-Alpha）是一种干扰素，属于干扰素家族的一种细胞因子。干扰素是一类哺乳动物细胞因子，具有调节免疫反应和抗病毒能力的作用。它们由大多数细胞类型合成和分泌，以应对病原体。除了抗病毒特性外，干扰素还被证明具有抗增殖、免疫调节以及许多其他活性。

在人类中，IFN-α由一组氨基酸序列同源性大于85%的蛋白质组成。已鉴定出许多个人类IFN-α亚型；许多显示不同的属性。目前尚不清楚为什么有多种IFN-α亚型。各种研究表明，它们具有重叠但又独特的生物活性。

我们推荐高灵敏度的人IFN-α全亚型ELISA试剂盒旨在对自身免疫血清、正常血清、EDTA 血浆和组织培养基（TCM）中的所有人IFN-α亚型进行准确的低 pg/ml 测量。提供了一种可靠且灵敏的方法，因此对于免疫学、炎症和治疗药物监测方面的研究非常有价值。作为PBL Assay Science在中国区域的代理商，艾美捷科技将为中国客户提供全面的PBL Assay Science产品以及客户订制化服务。欢迎大家随时联系我们。

高灵敏度的人IFN-α全亚型ELISA试剂盒（货号：41115）
样品类型	血清、血浆、组织培养基
检测范围	1.95 - 125 pg/ml
灵敏度（LLOQ）	1.95 pg/ml
特异性	人IFN-α，检测所有12种IFN-α亚型，以准确地测量样品的总量。
变异系数和加标回收率	Inter-Assay: ≤ 10% Intra-Assay: ≤ 8% Spike Recovery: ≥ 80% in Serum
该试剂盒测试的正常人血清中干扰素α各亚型的代表性定量下限和检测下限(pg/ml)	专为检测人类所有IFN-α亚型而设计。
Protocol
典型标准曲线
正常人血清中IFN-α亚型标准曲线

引用文献（Citations）：

1. Ou, B.S. et al., (2024), "Nanoparticle-Conjugated Toll-Like Receptor 9 Agonists Improve the Potency, Durability, and Breadth of COVID-19 Vaccines", ACS NanoDOI: 10.1021/acsnano.3c09700
2. Biava, M. et al., (2023), "In Vitro and In Vivo Crosstalk between Type I IFN and IL-8 Responses in SARS-CoV-2 Infection", Microorganisms, 11(11):2787, PMID: 38004798, DOI: 10.3390/microorganisms11112787
3. Grunhagel, B., et al., (2023), "Reduction of IFN-I Responses by Plasmacytoid Dendritic Cells in a Longitudinal Trans Men Cohort, iScience, DOI: 10.1016/j.isci.2023.108209
4. Nagaoka, K. et al., (2023), "Dominant CT Patterns and Immune Responses during the Early Infection Phases of Different SARS-CoV-2 Variants", Viruses, 15:1304, DOI: 10.3390/v15061304
5. Kida, Y. et al., (2023), "Lethal Interstitial Lung Disease Associated with a Gain-of-Function Mutation in IFIH1",  Clin Immunol., PMID: 37126154, DOI: 10.1007/s10875-023-01494-8
6. Kim, S.T. et al., (2023). "Interferon and interferon-induced cytokines as markers of impending clinical progression in ANA+ individuals without a systemic autoimmune rheumatic disease diagnosis", Arthritis Res. Ther., PMID: 36765391, DOI: 10.1186/s13075-023-02997-w
7. Bibby, J.A., et al., (2022), "Systematic single-cell pathway analysis to characterize early T cell activation, Cell Rep., 41(8):111697, PMID: 36417885, DOI: 10.1016/j.cellrep.2022.111697
8. Rajamanickam, A. et al., (2022), "Restoration of dendritic cell homeostasis and Type I/Type III interferon levels in convalescent COVID-19 individuals, BMC Immunol., 23(1):51, PMID: 36289478, DOI: 10.1186/s12865-022-00526-z
9. Kubo, S. et al., (2022), "Lactoferrin and its digestive peptides induce interferon-a production and activate plasmacytoid dendritic cells ex vivo", Biometals, PMID: 36018422, DOI: 10.1007/s10534-022-00436-y
10. Nagaoka, N., et al., (2022), "Effect of Casirivimab/Imdevimab Treatment on Serum Type I Interferon Levels in SARS-CoV-2 Infection", Viruses, 14(7):1399, DOI: 10.3390/v14071399
11. Edahiro, Y., Ohishi, K., Gotoh, A. et al., (2022),  "Efficacy and safety of ropeginterferon alfa-2b in Japanese patients with polycythemia vera: an open-label, single-arm, phase 2 study",  J. Hematol., PMID: 35430707, DOI: 10.1007/s12185-022-03341-9 
12. Kanazawa, N. et al.,(2021), Heterozygous missense variant of the proteasome subunit β-type 9 causes neonatal-onset autoinflammation and immunodeficiency, Nature Communications, 12:6819, DOI: 10.1038/s41467-021-27085-y
13. Jablonska, A., et al.,  (2021), The TLR92848C/T Polymorphism Is Associated with the CMV DNAemia among HIV/CMV Co-Infected Patients, Cells, 10:2360, DOI: 10.3390/cells10092360,
14. Peluso, Michael, et al.(2020). Liver function test abnormalities in a longitudinal cohort of Thai individuals treated since acute HIV infection. PLOS Pathogens, 9 pgs. PMID: 31953919.
15. Dagenais-Lussier, Xavier, et al.(2019). USP18 is a significant driver of memory CD4 T-cell reduced viability caused by type I IFN signaling during primary HIV-1 infection. PLOS Pathogens, 32 pgs. PMID: 31658294.
16. Colavita, Francesca, et al.(2018). Overproduction of IL-6 and Type-I IFN in a Lethal Case of Chikungunya Virus Infection in an Elderly Man During the 2017 Italian Outbreak. Open Forum Infectious Diseases, 21 pgs. PMID: 30539034.
17. Williams, Dionna, et al.(2018). CCR2 Signaling Selectively Regulates IFN-alpha: Role of Beta-Arrestin 2 in IFNAR1 Internalization. Journal of Immunology, 19 pgs. PMID: 30504423.
18. Zhang, Guoliang, et al.(2018). A Proline Deletion in IFNAR1 Impairs IFN-Signaling and Underlies Increased Resistance to Tuberculosis in Humans. Nature Communications, 9 pgs. PMID: 29311663.
19. Murayama, Goh, et al. (2017). Enhanced IFN-alpha Production is Associated with Increased TLR7 Retention in the Lysosomes of Palasmacytoid Dendritic Cells in Systemic Lupus Erythematosus. Arthritis Research & Therapy, 11 pgs. PMID: 29052537.
20. Wither, Joan, et al. (2017). Presence of an Interferon Signature in Individuals Who are Anti-Nuclear Antibody Positive Lacking a Systemic Autoimmune Rheumatic Disease Diagnosis. Arthritis Research & Therapy, 11 pgs. PMID: 28245862.
21. Vanheule, Vincent, et al. (2016). Basic Chemokine-Derived Glycosaminoglycan Binding Peptides Exert Antiviral Properties Against Dengue Virus Serotype 2, Herpes Simplex Virus-1, and Respiratory Syncytial Virus. Biochemical Pharmacology, 13 pgs. PMID: 26551597.
22. Combes, Alexis, et al. (2020). Global Absence and Targeting of Protective Immune States in Severe COVID-19. Nature, 36 pgs.

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美国的PBL Assay Science（又名：Pestka Biomedical Laboratories, Inc.）成立于1990年，创始人Sidney Pestka被称为“干扰素之父”，PBL Assay Science 作为干扰素和细胞因子蛋白和抗体以及预包装的一流的干扰素和细胞因子免疫测定试剂盒的高质量制造商而享有盛誉。生产和销售的高品质干扰素产品和生物标志物检测试剂盒在很多高影响力出版物中都有引用，并已在具有挑战性的样本中进行了外部验证。

PBL Assay Science提供各种干扰素亚型的蛋白，抗体和检测试剂盒，如：IFN-Alpha（IFN-ɑ 2a，IFN-ɑ 2b，IFN-ɑ 5，IFN-ɑ 6，IFN-ɑ 7，IFN-ɑ 14，IFN-ɑ 16，IFN-ɑ 17......），IFN-Beta（IFN-β 1a，IFN-β 1b），IFN-Lambda（IFN-λ），IFN-Omega（IFN-ω），IFN-Gamma（IFN-γ）......

武汉艾美捷科技有限公司，简称艾美捷，拥有进出口资质和自己的国际物流，与国内外90余家知名的试剂、原料及技术服务供应商深度合作，是国内生物制药企业、诊断企业、跨国药企、各大高校院所采购平台的首选定供应商。