Voltage-sensitive Ca2+ channels (VSCC) play a central role in an extensive array of physiological processes. Their importance in cellular function arises from their ability both to sense membrane voltage and to conduct Ca2+ ions, two facets that couple membrane excitability to a key intracellular second messenger. Through this relationship, activation of VSCCs is tightly coupled to the gamut of cellular functions dependent on intracellular Ca2+ , including muscle contraction, energy metabolism, gene expression, and exocytotic/endocytotic cycling.
