EpiQuik™ 总组蛋白提取试剂盒是一整套优化的缓冲液和试剂，用于在简单的 60 分钟程序中从哺乳动物细胞或组织中提取总核心组蛋白（H2A、H2B、H3 和 H4）。组蛋白提取物中的翻译后修饰 （PTM） 保持完整，因此可与 Epigentek 的组蛋白修饰检测试剂盒一起使用，或用于组蛋白甲基化、乙酰化、磷酸化、苏木化、泛素化、瓜氨酸化和 ADP 核糖基化研究的各种下游应用。
- 预先优化且简单的 1 小时方案。
- 方便地包括进行组蛋白提取所需的所有必需试剂。
- 标准化程序，结果可重复。
- 从低至 1 mg 的组织中提取高产量的总核心组蛋白。
- 翻译后修饰保持完整。
- 不影响组蛋白修饰状态或水平。
| 产品名称 | 货号 | 规格 |
| EpiQuik 总组蛋白提取试剂盒
EpiQuik Total Histone Extraction Kit |
OP-0006-100 | 100 extractions |
近400+文献鉴赏：
| 标题 | 作者 | 杂志名称 |
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| Anticancer efficacy of cisplatin and trichostatin A or 5-aza-2'-deoxycytidine on ovarian cancer. | Meng F, Sun G, Zhong M, Yu Y, Brewer MA | Br J Cancer |
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| Feeding a high-concentrate corn straw diet induced epigenetic alterations in the mammary tissue of dairy cows. | Dong G, Qiu M, Ao C, Zhou J, Khas-Erdene, Wang X, Zhang Z, Yang Y | PLoS One |
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| Histone H3 Phosphorylation in GBM: a New Rational to Guide the Use of Kinase Inhibitors in anti-GBM Therapy. | Pacaud R, Cheray M, Nadaradjane A, Vallette FM, Cartron PF | Theranostics |
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| Liver histone H3 methylation and acetylation may associate with type 2 diabetes development. | Tu P, Li X, Ma B, Duan H, Zhang Y, Wu R, Ni Z, Jiang P, Wang H, Li M, Zhu J, Li M | J Physiol Biochem |
| Small antisense oligonucleotides against G-quadruplexes: specific mRNA translational switches. | Rouleau SG, Beaudoin JD, Bisaillon M, Perreault JP | Nucleic Acids Res |
| Design, Synthesis, and Structure-Activity Relationship of Novel LSD1 Inhibitors Based on Pyrimidine-Thiourea Hybrids As Potent, Orally Active Antitumor Agents. | Ma LY, Zheng YC, Wang SQ, Wang B, Wang ZR, Pang LP, Zhang M, Wang JW, Ding L, Li J, Wang C, Hu B, Liu Y, Zhang XD, Wang JJ, Wang ZJ, Zhao W, Liu HM | J Med Chem |
| First-in-human study of the toxicity, pharmacokinetics, and pharmacodynamics of CG200745, a pan-HDAC inhibitor, in patients with refractory solid malignancies. | Kim KP, Park SJ, Kim JE, Hong YS, Lee JL, Bae KS, Cha H, Kwon SK, Ro S, Cho J, Kim TW | Invest New Drugs |
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| Developmental lead exposure and lifespan alterations in epigenetic regulators and their correspondence to biomarkers of Alzheimer's disease | Eid A, Bihaqi S, Renehan W, Zawaia N | Alzheimer's and Dement |
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| H3K9me3 Inhibition Improves Memory, Promotes Spine Formation, and Increases BDNF Levels in the Aged Hippocampus. | Snigdha S, Prieto GA, Petrosyan A, Loertscher BM, Dieskau AP, Overman LE, Cotman CW | J Neurosci |
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| 1,2,3-Triazole-Dithiocarbamate Hybrids, a Group of Novel Cell Active SIRT1 Inhibitors. | Zheng YC, Wang LZ, Zhao LJ, Zhao LJ, Zhan QN, Ma JL, Zhang B, Wang MM, Wang ZR, Li JF, Liu Y, Chen ZS, Shen DD, Liu XQ, Ren M, Lv WL, Zhao W, Duan YC, Liu HM | Cell Physiol Biochem |
| Quiescence Loosens Epigenetic Constraints in Bovine Somatic Cells and Improves Their Reprogramming into Totipotency. | Kallingappa PK, Turner PM, Eichenlaub MP, Green AL, Oback FC, Chibnall AM, Wells DN, Oback B | Biol Reprod |
| Frontline Science: ATF3 is responsible for the inhibition of TNF-α release and the impaired migration of acute ethanol-exposed monocytes and macrophages. | Hu C, Meng X, Huang C, Shen C, Li J | J Leukoc Biol |
| Dynamic Variation of Histone H3 Trimethyl Lys4 (H3K4me3) and Heterochromatin Protein 1 (HP1) with Employment Length in Nickel Smelting Workers. | Zhao Y, Cheng N, Dai M, Pu H, Zheng T, Li H, He J, Bai Y | Biomarkers |
| Characteristics and expression patterns of histone-modifying enzyme systems in the migratory locust. | Guo S, Jiang F, Yang P, Liu Q, Wang X, Kang L | Insect Biochem Mol Biol |
| Lack of global epigenetic methylation defects in CBS deficient mice. | Lee HO, Wang L, Kuo YM, Gupta S, Slifker MJ, Li YS, Andrews AJ, Kruger WD | J Inherit Metab Dis |
| Tip60 HAT Action Mediates Environmental Enrichment Induced Cognitive Restoration. | Xu S, Panikker P, Iqbal S, Elefant F | PLoS One |
| Abnormal histone acetylation of CD8+ T cells in patients with severe aplastic anemia. | Qi W, Yan L, Liu C, Fu R, Wang H, Shao Z | Int J Hematol |
| Histone deacetylase inhibition is cytotoxic to oligodendrocyte precursor cells in vitro and in vivo. | Dincman TA, Beare JE, Ohri SS, Gallo V, Hetman M, Whittemore SR | Int J Dev Neurosci |
| miR-15b facilitates the progression of colorectal cancer via targeting β-catenin and Axin2 | Xiong Guo, Yang Zhang, Jian Li, Mingmei Liao | IJCEP |
| Dietary Flavones as Dual Inhibitors of DNA Methyltransferases and Histone Methyltransferases. | Kanwal R, Datt M, Liu X, Gupta S | PLoS One |
| CD47 is a Potential Target for the Treatment of Laryngeal Squamous Cell Carcinoma. | Yang C, Gao S, Zhang H, Xu L, Liu J, Wang M, Zhang S | Cell Physiol Biochem |
| Mutations in Histone Acetylase Modifier BRPF1 Cause an Autosomal-Dominant Form of Intellectual Disability with Associated Ptosis | Francesca Mattioli, Elise Schaefer, Alex Magee, Paul Mark, Grazia M. Mancini, Klaus Dieterich, Gretchen Von Allmen et al. | AJHG |
| Development of Improved HDAC6 Inhibitors as Pharmacological Therapy for Axonal Charcot-Marie-Tooth Disease. | Benoy V, Vanden Berghe P, Jarpe M, Van Damme P, Robberecht W, Van Den Bosch L | Neurotherapeutics |
| Selective Inhibitors of Histone Deacetylases 1 and 2 Synergize with Azacitidine in Acute Myeloid Leukemia. | Min C, Moore N, Shearstone JR, Quayle SN, Huang P, van Duzer JH, Jarpe MB, Jones SS, Yang M | PLoS One |
| Phosphorylated Histone 3 at Serine 10 Identifies Activated Spinal Neurons and Contributes to the Development of Tissue Injury-Associated Pain. | Torres-Pérez JV, Sántha P, Varga A, Szucs P, Sousa-Valente J, Gaal B, Sivadó M, Andreou AP, Beattie S, Nagy B, Matesz K, C Arthur JS, Jancsó G, Nagy I | Sci Rep |
| Histone H4 expression is cooperatively maintained by IKKβ and Akt1 which attenuates cisplatin-induced apoptosis through the DNA-PK/RIP1/IAPs signaling cascade. | Wang R, Zheng X, Zhang L, Zhou B, Hu H, Li Z, Zhang L, Lin Y, Wang X | Sci Rep |
| Involvement of histone methylation in macrophage apoptosis and unstable plaque formation in methionine-induced hyperhomocysteinemic ApoE<sup>-/-</sup> mice. | Cong G, Yan R, Huang H, Wang K, Yan N, Jin P, Zhang N, Hou J, Chen D, Jia S | Life Sci |
| In utero exposure to germinated brown rice and its oryzanol-rich extract attenuated high fat diet-induced insulin resistance in F1 generation of rats. | Adamu HA, Imam MU, Ooi DJ, Esa NM, Rosli R, Ismail M | BMC Complement Altern Med |
| Dose- and time- effect responses of DNA methylation and histone H3K9 acetylation changes induced by traffic-related air pollution. | Ding R, Jin Y, Liu X, Ye H, Zhu Z, Zhang Y, Wang T, Xu Y | Sci Rep |
| Alkylresorcinols activate SIRT1 and delay ageing in Drosophila melanogaster. | Kayashima Y, Katayanagi Y, Tanaka K, Fukutomi R, Hiramoto S, Imai S | Sci Rep |
| Citrullination/Methylation Crosstalk on Histone H3 Regulates ER-Target Gene Transcription. | Clancy KW, Russell AM, Subramanian V, Nguyen H, Qian Y, Campbell RM, Thompson PR | ACS Chem Biol |
| Loss of TET1 facilitates DLD1 colon cancer cell migration via H3K27me3-mediated down-regulation of E-cadherin. | Zhou Z, Zhang HS, Liu Y, Zhang ZG, Du GY, Li H, Yu XY, Huang YH | J Cell Physiol |
| Epigenetic mechanisms underlying NMDA receptor hypofunction in the prefrontal cortex of juvenile animals in the MAM model for schizophrenia. | Gulchina Y, Xu SJ, Snyder MA, Elefant F, Gao WJ | J Neurochem |
| Response gene to complement-32 mediates TGF-β-induced epithelial-mesenchymal transition via Erk-/p38-MAPK signaling pathways in human pancreatic cancer cell line BxPC-3 | Liang Zhu, Ying Ding, Qiu Zhao | IJCEP |
| MicroRNA‑320 regulates autophagy in retinoblastoma by targeting hypoxia inducible factor‑1α | Yong Liang, Xi Chen, Zhu Liang | Experimental and Theraputic Medicine |
| BEBT-908: A novel potent PI3K/HDAC inhibitor against diffuse large B-cell lymphoma. | Li J, Qian C, Zhou Q, Li J, Li K, Yi P | Biochem Biophys Res Commun |
| Oncometabolite d-2-hydroxyglutarate impairs α-ketoglutarate dehydrogenase and contractile function in rodent heart. | Karlstaedt A, Zhang X, Vitrac H, Harmancey R, Vasquez H, Wang JH, Goodell MA, Taegtmeyer H | Proc Natl Acad Sci U S A |
| Hepatic Lipid Accumulation and Nrf2 Expression following Perinatal and Peripubertal Exposure to Bisphenol A in a Mouse Model of Nonalcoholic Liver Disease | Shimpi P, More V, Paranjpe M, Donepudi A, Goodrich J, Dolinoy D, Beverly Rubin B, Slitt A. | Environmental Health Perspective |
| KDM4B-mediated reduction of H3K9me3 and H3K36me3 levels improves somatic cell reprogramming into pluripotency. | Wei J, Antony J, Meng F, MacLean P, Rhind R, Laible G, Oback B | Sci Rep |
| Chemoproteomics Reveals Chemical Diversity and Dynamics of 4-Oxo-2-nonenal Modifications in Cells. | Sun R, Fu L, Liu KK, Tian CP, Yang Y, Tallman KA, Porter NA, Liebler DC, Yang J | Mol Cell Proteomics |
| Systematic and quantitative assessment of hydrogen peroxide reactivity with cysteines across human proteomes. | Fu L, Liu KK, Sun MA, Tian CP, Sun R, Morales Betanzos C, Tallman KA, Porter NA, Yang Y, Guo DJ, Liebler DC, Yang J | Mol Cell Proteomics |
| Chronic exercise training activates histone turnover in mouse skeletal muscle fibers. | Ohsawa I, Kawano F | FASEB J |
| Novel detection of post-translational modifications in human monocyte-derived dendritic cells after chronic alcohol exposure: Role of inflammation regulator H4K12ac. | Parira T, Figueroa G, Laverde A, Casteleiro G, Gomez Hernandez ME, Fernandez-Lima F, Agudelo M | Sci Rep |
| The Oxidative State of Cysteine Thiol 144 Regulates the SIRT6 Glucose Homeostat. | Long D, Wu H, Tsang AW, Poole LB, Yoza BK, Wang X, Vachharajani V, Furdui CM, McCall CE | Sci Rep |
| Sirt1 regulates apoptosis and extracellular matrix degradation in resveratrol‑treated osteoarthritis chondrocytes via the Wnt/β‑catenin signaling pathways | Liu, S., Yang, H., Hu, B., Zhang, M. | Experimental and Therapeutic Medicine |
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| Serum CCL20 and its association with SIRT1 activity in multiple sclerosis patients | Rui Li, Xiaobo Sun, Yaqing Shu, Yuge Wang, Li Xiao, Zhanhang Wang, Xueqiang Hu, Allan G. Kermode, Wei Qiu | Journal of Neuroimmunology |
| Acute Strenuous Exercise Induces an Imbalance on Histone H4 Acetylation/Histone Deacetylase 2 and Increases the Proinflammatory Profile of PBMC of Obese Individuals | Gilson P. Dorneles, Maria Carolina R. Boeira, Lucas L. Schipper, et al. | Oxidative Medicine and Cellular Longevity |
| iTRAQ-Based Proteomic Analysis of Neonatal Kidney from Offspring of Protein Restricted Rats Reveals Abnormalities in Intraflagellar Transport Proteins. | Liu X, Wang J, Gao L, Liu H, Liu C | Cell Physiol Biochem |
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| The protective role of DOT1L in UV-induced melanomagenesis. | Zhu B, Chen S, Wang H, Yin C, Han C, Peng C, Liu Z, Wan L, Zhang X, Zhang J, Lian CG, Ma P, Xu ZX, Prince S, Wang T, Gao X, Shi Y, Liu D, Liu M, Wei W, Wei Z, Pan J, Wang Y, Xuan Z, Hess J, Hayward NK, Goding CR, Chen X, Zhou J, Cui R | Nat Commun |
| WOX11 recruits a histone H3K27me3 demethylase to promote gene expression during shoot development in rice. | Cheng S, Tan F, Lu Y, Liu X, Li T, Yuan W, Zhao Y, Zhou DX | Nucleic Acids Res |
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| DZNep inhibits H3K27me3 deposition and delays retinal degeneration in the rd1 mice. | Zheng S, Xiao L, Liu Y, Wang Y, Cheng L, Zhang J, Yan N, Chen D | Cell Death Dis |
| Histone methylation-associated transgenerational inheritance of reproductive defects in Caenorhabditis elegans exposed to crude oil under various exposure scenarios. | Yang J, Chatterjee N, Kim Y, Roh JY, Kwon JH, Park MS, Choi J | Chemosphere |
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| Alterations in histone acetylation following exposure to 60Co γ-rays and their relationship with chromosome damage in human lymphoblastoid cells. | Tian XL, Lu X, Feng JB, Cai TJ, Li S, Tian M, Liu QJ | Radiat Environ Biophys |
| Mapping dynamic histone modification patterns during arsenic-induced malignant transformation of human bladder cells. | Ge Y, Zhu J, Wang X, Zheng N, Tu C, Qu J, Ren X | Toxicol Appl Pharmacol |
| Selective DOT1L, LSD1, and HDAC class I inhibitors reduce HOXA9 expression in MLL-AF9 rearranged leukemia cells, but dysregulate the expression of many histone-modifying enzymes. | Lillico R, Lawrence CK, Lakowski TM | J Proteome Res |
| Acetylation blocks DNA damage-induced chromatin ADP-ribosylation. | Liszczak G, Diehl KL, Dann GP, Muir TW | Nat Chem Biol |
| Integrated approach of eco-epigenetics and eco-metabolomics on the stress response of bisphenol-A exposure in the aquatic midge Chironomus riparius. | Lee SW, Chatterjee N, Im JE, Yoon D, Kim S, Choi J | Ecotoxicol Environ Saf |
| The histone demethylase KDM6B in the medial prefrontal cortex epigenetically regulates cocaine reward memory. | Zhang YX, Akumuo RC, España RA, Yan CX, Gao WJ, Li YC | Neuropharmacology |
| Metabolic gene expression and epigenetic effects of the ketone body β-hydroxybutyrate on H3K9ac in bovine cells, oocytes and embryos. | Sangalli JR, Sampaio RV, Del Collado M, da Silveira JC, De Bem THC, Perecin F, Smith LC, Meirelles FV | Sci Rep |
| Dynamics and functional interplay of histone lysine butyrylation, crotonylation, and acetylation in rice under starvation and submergence. | Lu Y, Xu Q, Liu Y, Yu Y, Cheng ZY, Zhao Y, Zhou DX | Genome Biol |
| Histone modifications associated with biological drug response in moderate-to-severe psoriasis. | Ovejero-Benito MC, Reolid A, Sánchez-Jiménez P, Saiz-RodrÃguez M, Muñoz-Aceituno E, Llamas-Velasco M, MartÃn-Vilchez S, Cabaleiro T, Román M, Ochoa D, Daudén E, Abad-Santos F | Exp Dermatol |
| Hydrogen Sulfide Promotes Bone Homeostasis by Balancing Inflammatory Cytokine Signaling in CBS-Deficient Mice through an Epigenetic Mechanism. | Behera J, Kelly KE, Voor MJ, Metreveli N, Tyagi SC, Tyagi N | Sci Rep |
| Aberrant histone modification and inflammatory cytokine production of peripheral CD4+ T cells in patients with oral lichen planus. | Shen J, Yin C, Jiang X, Wang X, Yang S, Song G | J Oral Pathol Med |
| Reduced AMPK activation and increased HCAR activation drive anti-inflammatory response and neuroprotection in glaucoma. | Harun-Or-Rashid M, Inman DM | J Neuroinflammation |
| Characterization of H3 methylation in regulating oocyte development in cyprinid fish. | Zhou R, Shang R, Gong D, Xu X, Liu S | Sci China Life Sci |
| Enhanced histone H3K9 tri-methylation suppresses steroidogenesis in rat testis chronically exposed to arsenic. | Alamdar A, Tian M, Huang Q, Du X, Zhang J, Liu L, Shah STA, Shen H | Ecotoxicol Environ Saf |
| The histone deacetylase NlHDAC1 regulates both female and male fertility in the brown planthopper, Nilaparvata lugens | Zhang J.L et al. | Open Biology |
| Latent role of in vitro Pb exposure in blocking Aβ clearance and triggering epigenetic modifications. | Wang Y, Hu Y, Wu Z, Su Y, Ba Y, Zhang H, Li X, Cheng X, Li W, Huang H | Environ Toxicol Pharmacol |
| Histone demethylase KDM6B has an anti-tumorigenic function in neuroblastoma by promoting differentiation. | Yang L, Zha Y, Ding J, Ye B, Liu M, Yan C, Dong Z, Cui H, Ding HF | Oncogenesis |
| Epigenetic biomarker screening by FLIM-FRET for combination therapy in ER+ breast cancer. | Liu W, Cui Y, Ren W, Irudayaraj J | Clin Epigenetics |
| The role of histone H3K27 dimethylation in early-stage urinary bladder carcinoma: the relevance of risk factor | Salama Ragaa H, Gaber Marwa A, Rezk Khalid M, Hamed Samia F | JCMRP |
| MS-275 induces hepatic FGF21 expression via H3K18ac-mediated CREBH signal. | Zhang Q, Zhu Q, Ruyuan D, Zhou F, Zhang L, Wang S, Zhu K, Xiao W, Libin Z, Su Q | J Mol Endocrinol |
| Novel CHK1 inhibitor MU380 exhibits significant single-agent activity in TP53-mutated chronic lymphocytic leukemia cells. | Boudny M, Zemanova J, Khirsariya P, Borsky M, Verner J, Cerna J, Oltova A, Seda V, Mraz M, Jaros J, Jaskova Z, Spunarova M, Brychtova Y, Soucek K, Drapela S, Kasparkova M, Mayer J, Paruch K, Trbusek M | Haematologica |
| Epigenetic regulation of regulatory T cells in patients with abdominal aortic aneurysm. | Xia Q, Zhang J, Han Y, Zhang X, Jiang H, Lun Y, Wu X, Gang Q, Liu Z, Böckler D, Duan Z, Xin S | FEBS Open Bio |
| Human osteogenic differentiation in Space: proteomic and epigenetic clues to better understand osteoporosis. | Gambacurta A, Merlini G, Ruggiero C, Diedenhofen G, Battista N, Bari M, Balsamo M, Piccirillo S, Valentini G, Mascetti G, Maccarrone M | Sci Rep |
| SCD1 regulates the AMPK/SIRT1 pathway and histone acetylation through changes in adenine nucleotide metabolism in skeletal muscle. | Dziewulska A, Dobosz AM, Dobrzyn A, Smolinska A, Kolczynska K, Ntambi JM, Dobrzyn P | J Cell Physiol |
| Chemical genomics reveals histone deacetylases are required for core regulatory transcription. | Gryder BE, Wu L, Woldemichael GM, Pomella S, Quinn TR, Park PMC, Cleveland A, Stanton BZ, Song Y, Rota R, Wiest O, Yohe ME, Shern JF, Qi J, Khan J | Nat Commun |
| Targeted demethylation of H3K9me3 and H3K36me3 improves somatic cell reprogramming into cloned preimplantation but not postimplantation bovine concepti | Meng F, Stamms K, et al. | bioRxiv |
| Asymmetrical methyltransferase PRMT3 regulates human mesenchymal stem cell osteogenesis via miR-3648. | Min Z, Xiaomeng L, Zheng L, Yangge D, Xuejiao L, Longwei L, Xiao Z, Yunsong L, Ping Z, Yongsheng Z | Cell Death Dis |
| The repositioning of epigenetic probes/inhibitors identifies new anti-schistosomal lead compounds and chemotherapeutic targets. | Whatley K. C. L, et al. | biorxiv |
| A 2x folic acid treatment affects epigenetics and dendritic spine densities in SHSY5Y cells. | Al Sayed R, Smith W, Rogers N, Smith N, Clark D, Castillo G, McLeod H, Glenister S, Shorter KR | Biochem Biophys Rep |
| Cross-talk between energy metabolism and epigenetics during temperature stress response in C2C12 myoblasts. | Sajjanar B, Siengdee P, Trakooljul N, Liu X, Kalbe C, Wimmers K, Ponsuksili S | Int J Hyperthermia |
| Global and region-specific post-transcriptional and post-translational modifications of bisphenol A in human prostate cancer cells | Karaman E. F, Caglayan M, et. al. | Environmental Pollution |
| Bacterial Pathogens Hijack the Innate Immune Response by Activation of the Reverse Transsulfuration Pathway. | Gobert AP, Latour YL, Asim M, Finley JL, Verriere TG, Barry DP, Milne GL, Luis PB, Schneider C, Rivera ES, Lindsey-Rose K, Schey KL, Delgado AG, Sierra JC, Piazuelo MB, Wilson KT | MBio |
| Glucose-induced microRNA-218 suppresses the proliferation and promotes the apoptosis of human retinal pigment epithelium cells by targeting RUNX2. | Yao R, Yao X, Liu R, Peng J, Tian T | Biosci Rep |
| Epigenetic regulations in alternative telomere lengthening: Understanding the mechanistic insight in arsenic-induced skin cancer patients. | Bhattacharjee P, Das A, Giri AK, Bhattacharjee P | Sci Total Environ |
| The Dopamine Receptor Antagonist TFP Prevents Phenotype Conversion and Improves Survival in Mouse Models of Glioblastoma | Bhat, K et. al | bioRxiv |
| Reduced H3K27me3 leads to abnormal Hox gene expression in neural tube defects. | Yu J, Wang L, Pei P, Li X, Wu J, Qiu Z, Zhang J, Ao R, Wang S, Zhang T, Xie J | Epigenetics Chromatin |
| Histone H3K9 methylation is involved in temporomandibular joint osteoarthritis. | Ukita M, Matsushita K, Tamura M, Yamaguchi T | Int J Mol Med |
| SAHA and EGCG Promote Apoptosis in Triple-negative Breast Cancer Cells, Possibly Through the Modulation of cIAP2. | Steed KL, Jordan HR, Tollefsbol TO | Anticancer Res |
| Elevated histone H3 citrullination is associated with increased Beclin1 expression in HBV-related hepatocellular carcinoma. | Lu M, Zhang X, Xu Y, He G, Liu Q, Zhu J, Zhang C | J Med Virol |
| HDAC1 and HDAC2 regulate anti-inflammatory effects of anesthetic isoflurane in human monocytes. | Guo X, Deng J, Zheng B, Liu H, Zhang Y, Ying Y, Jia J, Ruan X | Immunol Cell Biol |
| Exploration of 5-cyano-6-phenylpyrimidin derivatives containing an 1,2,3-triazole moiety as potent FAD-based LSD1 inhibitors | Ma L et. al. | Acta Pharmaceutica Sinica B |
| Angiotensin II represses Npr1 expression and receptor function by recruitment of transcription factors CREB and HSF-4a and activation of HDACs. | Arise KK, Kumar P, Garg R, Samivel R, Zhao H, Pandya K, Nguyen C, Lindsey S, Pandey KN | Sci Rep |
| Force-induced gene up-regulation does not follow the weak power law but depends on H3K9 demethylation. | Sun J, Chen J, Mohagheghian E, Wang N | Sci Adv |
| Histone demethylase SlJMJ6 promotes fruit ripening by removing H3K27 methylation of ripening-related genes in tomato. | Li Z, Jiang G, Liu X, Ding X, Zhang D, Wang X, Zhou Y, Yan H, Li T, Wu K, Jiang Y, Duan X | New Phytol |
| Cloning and Expression Analysis of Two Kdm Lysine Demethylases in the Testes of Mature Yaks and Their Sterile Hybrids. | Shen Z, Huang L, Jin S, Zheng Y | Animals (Basel) |
| Targeted histone demethylation improves somatic cell reprogramming into cloned blastocysts but not postimplantation bovine concepti. | Meng F, Stamms K, Bennewitz R, Green A, Oback F, Turner P, Wei J, Oback B | Biol Reprod |
| Discovery, Structure-Activity Relationship, and Biological Activity of Histone-Competitive Inhibitors of Histone Acetyltransferases P300/CBP. | Wu F, Hua Y, Kaochar S, Nie S, Lin YL, Yao Y, Wu J, Wu X, Fu X, Schiff R, Davis CM, Robertson M, Ehli EA, Coarfa C, Mitsiades N, Song Y | J Med Chem |
| Relationship between occupational aluminium exposure and histone lysine modification through methylation | Pan B, et al. | Journal of Trace Elements in Medicine and Biology |
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| Abnormal Histones Acetylation In Patients With Primary Sjögren’s Syndrome | Li, Y et. al | Research Square |
| Protein acetylation derepresses Serotonin Synthesis to potentiate Pancreatic Beta-Cell Function through HDAC1-PKA-Tph1 signaling. | Zhang Y, Wang S, Zhang L, Zhou F, Zhu K, Zhu Q, Liu Q, Liu Y, Jiang L, Ning G, Bi Y, Zhou L, Wang X | Theranostics |
| Identification of 6-(piperazin-1-yl)-1,3,5-triazine as a chemical scaffold with broad anti-schistosomal activities. | Padalino G, Chalmers IW, Brancale A, Hoffmann KF | Wellcome Open Res |
| Isoform-specific characterization of class I histone deacetylases and their therapeutic modulation in pulmonary hypertension. | Chelladurai P, Dabral S, Basineni SR, Chen CN, Schmoranzer M, Bender N, Feld C, Nötzold RR, Dobreva G, Wilhelm J, Jungblut B, Zhao L, Bauer UM, Seeger W, Pullamsetti SS | Sci Rep |
| Immuno-cytometric detection of circulating cell free methylated DNA, post-translationally modified histones and micro RNAs using semi-conducting nanocrystals | Shandilya R. et. al. | Talanta |
| Effects of mineral methionine hydroxy analogue chelate in sow diets on epigenetic modification and growth of progeny. | Jang K, Kim JH, Purvis JM, Chen J, Ren P, Vazquez-Anon M, Kim SW | J Anim Sci |
| Regulation of a long noncoding RNA MALAT1 by aryl hydrocarbon receptor in pancreatic cancer cells and tissues. | Lee JE, Cho SG, Ko SG, Ahrmad SA, Puga A, Kim K | Biochem Biophys Res Commun |
| Histone methylation status of H3K4me3 and H3K9me3 under methionine restriction is unstable in methionine-addicted cancer cells, but stable in normal cells. | Yamamoto J, Han Q, Inubushi S, Sugisawa N, Hamada K, Nishino H, Miyake K, Kumamoto T, Matsuyama R, Bouvet M, Endo I, Hoffman RM | Biochem Biophys Res Commun |
| Epigenetic Studies Revealed a Ghost Proteome in PC1/3 KD Macrophages under Antitumoral Resistance Induced by IL-10 | Cardon T. et. al. | ACS Omega |
| Perinatal inflammation alters histone 3 and histone 4 methylation patterns: Effects of MiR-29b supplementation. | Sugar SS, Heyob KM, Cheng X, Lee RJ, Rogers LK | Redox Biol |
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| A new ketogenic formulation improves functional outcome and reduces tissue loss following traumatic brain injury in adult mice. | Thau-Zuchman O, Svendsen L, Dyall SC, Paredes-Esquivel U, Rhodes M, Priestley JV, Feichtinger RG, Kofler B, Lotstra S, Verkuyl JM, Hageman RJ, Broersen LM, van Wijk N, Silva JP, Tremoleda JL, Michael-Titus AT | Theranostics |
| Histone benzoylation serves as an epigenetic mark for DPF and YEATS family proteins. | Ren X, Zhou Y, Xue Z, Hao N, Li Y, Guo X, Wang D, Shi X, Li H | Nucleic Acids Res |
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| Targeting the Histone Methyltransferase Disruptor of Telomeric Silencing 1-Like Restricts Avian Leukosis Virus Subgroup J Replication by Restoring the Innate Immune Response in Chicken Macrophages. | Chen S, Wang D, Liu Y, Zhao R, Wu T, Hu X, Pan Z, Cui H | Front Microbiol |
| Histone H3K4me3 and H3K9me3 are super over-methylated in soft tissue sarcoma compared to normal muscle in patient-derived xenograft (PDX) mouse models: an indicator of cancer methionine addiction | Aoki Y. et. al. | bioRxiv |
| Absence of S100A4 in the mouse lens induces an aberrant retina-specific differentiation program and cataract. | Maddala R, Gao J, Mathias RT, Lewis TR, Arshavsky VY, Levine A, Backer JM, Bresnick AR, Rao PV | Sci Rep |
| Rice and Arabidopsis homologs of yeast CHROMOSOME TRANSMISSION FIDELITY PROTEIN 4 commonly interact with Polycomb complexes but exert divergent regulatory functions | Zhang P, et. al. | The Plant Cell |
| Molecular profiling of epigenetic landscape of cancer cells during extracellular matrix detachment. | Khan MI, Zamzami MA, Ahmad A, Choudhry H | Sci Rep |
| Pharmacological inhibition of LSD1 for the treatment of MLL-rearranged leukemia. | Feng Z, Yao Y, Zhou C, Chen F, Wu F, Wei L, Liu W, Dong S, Redell M, Mo Q, Song Y | J Hematol Oncol |
| Metformin Reduces Histone H3K4me3 at the Promoter Regions of Positive Cell Cycle Regulatory Genes in Lung Cancer Cells. | Kim D, Kim Y, Lee BB, Cho EY, Han J, Shim YM, Kim DH | Cancers (Basel) |
| Stimulation of the Serotonin Receptor 7 Restores Brain Histone H3 Acetylation and MeCP2 Corepressor Protein Levels in a Female Mouse Model of Rett Syndrome. | Napoletani G, Vigli D, Cosentino L, Grieco M, Talamo MC, Lacivita E, Leopoldo M, Laviola G, Fuso A, d'Erme M, De Filippis B | J Neuropathol Exp Neurol |
| Psychostimulants and opioids differentially influence the epigenetic modification of histone acetyltransferase and histone deacetylase in astrocytes. | Doke M, Pendyala G, Samikkannu T | PLoS One |
| PRC2 loss of function confers a targetable vulnerability to BET proteins in T-ALL. | Andrieu GP, Kohn M, Simonin M, Smith C, Cieslak A, Dourthe ME, Charbonnier G, Graux C, Rigal-Huguet F, Lheritier V, Dombret H, Spicuglia S, Rousselot P, Boissel N, Asnafi V | Blood |
| Functional interplay of histone lysine 2-hydroxyisobutyrylation and acetylation in Arabidopsis under dark-induced starvation. | Zheng L, Li C, Ma X, Zhou H, Liu Y, Wang P, Yang H, Tamada Y, Huang J, Wang C, Hu Z, Wang X, Wang G, Li H, Hu J, Liu X, Zhou C, Zhang Y | Nucleic Acids Res |
| Pharmacological targeting of TNS3 with histone deacetylase inhibitor as a therapeutic strategy in esophageal squamous cell carcinoma. | Shi Y, Xiang Z, Yang H, Khan S, Li R, Zhou S, Ullah S, Zhang J, Liu B | Aging (Albany NY) |
| Anterograde regulation of mitochondrial genes and FGF21 signaling by hepatic LSD1. | Cao Y, Tang L, Du K, Paraiso K, Sun Q, Liu Z, Ye X, Fang Y, Yuan F, Chen YH, Chen Y, Wang X, Yu C, Blitz IL, Wang PH, Huang L, Cheng H, Lu X, Cho KW, Seldin M, Fang Z, Yang Q | JCI Insight |
| Allyl sulfide promotes osteoblast differentiation and bone density via reducing mitochondrial DNA release mediated Kdm6b/H3K27me3 epigenetic mechanism. | Behera J, Ison J, Rai H, Tyagi N | Biochem Biophys Res Commun |
| Exendin-4 may improve type 2 diabetes by modulating the epigenetic modifications of pancreatic histone H3 in STZ-induced diabetic C57BL/6Â J mice. | Tu P, Huang B, Li M, Zhang Y, Bao S, Tu N, Yang Y, Lu J | J Physiol Biochem |
| Mutant U2AF1-induced alternative splicing of H2afy (macroH2A1) regulates B-lymphopoiesis in mice. | Kim SP, Srivatsan SN, Chavez M, Shirai CL, White BS, Ahmed T, Alberti MO, Shao J, Nunley R, White LS, Bednarski J, Pehrson JR, Walter MJ | Cell Rep |
| Corticosterone dynamically regulates retrotransposable element expression in the rat hippocampus and C6 cells | Bartlett, A. A., et. al. | Neurobiology of Stress |
| Prenatal and postnatal traffic pollution exposure, DNA methylation in Shank3 and MeCP2 promoter regions, H3K4me3 and H3K27me3 and sociability in rats' offspring. | Zhou Q, Tian Y, Xu C, Wang J, Jin Y | Clin Epigenetics |
| Lactate supports a metabolic-epigenetic link in macrophage polarization. | Noe JT, Rendon BE, Geller AE, Conroy LR, Morrissey SM, Young LEA, Bruntz RC, Kim EJ, Wise-Mitchell A, Barbosa de Souza Rizzo M, Relich ER, Baby BV, Johnson LA, Affronti HC, McMasters KM, Clem BF, Gentry MS, Yan J, Wellen KE, Sun RC, Mitchell RA | Sci Adv |
| Histone H3 lysine-trimethylation markers are decreased by recombinant methioninase and increased by methotrexate at concentrations which inhibit methionine-addicted osteosarcoma cell proliferation. | Aoki Y, Tome Y, Han Q, Yamamoto J, Hamada K, Masaki N, Bouvet M, Nishida K, Hoffman RM | Biochem Biophys Rep |
| Epigenetic Silencing of OR and TAS2R Genes Expression in Human Orbitofrontal Cortex At Early Stages of Sporadic Alzheimer’s Disease | Cunha Alves, V., Figueiro-Silva, J.,Ferrer, I., Carro, E. | Research Square |
| Inhibition of class I HDACs preserves hair follicle inductivity in postnatal dermal cells. | Park M, Jang S, Chung JH, Kwon O, Jo SJ | Sci Rep |
| The long noncoding RNA H19 regulates tumor plasticity in neuroendocrine prostate cancer. | Singh N, Ramnarine VR, Song JH, Pandey R, Padi SKR, Nouri M, Olive V, Kobelev M, Okumura K, McCarthy D, Hanna MM, Mukherjee P, Sun B, Lee BR, Parker JB, Chakravarti D, Warfel NA, Zhou M, Bearss JJ, Gibb EA, Alshalalfa M, Karnes RJ, Small EJ, Aggarwal R, Feng F, Wang Y, Buttyan R, Zoubeidi A, Rubin M, Gleave M, Slack FJ, Davicioni E | Nat Commun |
| Blockage of citrate export prevents TCA cycle fragmentation via Irg1 inactivation. | Li Y, Li YC, Liu XT, Zhang L, Chen YH, Zhao Q, Gao W, Liu B, Yang H, Li P | Cell Rep |
| The histone demethylase PHF8 regulates TGFβ signaling and promotes melanoma metastasis. | Moubarak RS, de Pablos-Aragoneses A, Ortiz-Barahona V, Gong Y, Gowen M, Dolgalev I, Shadaloey SAA, Argibay D, Karz A, Von Itter R, Vega-Sáenz de Miera EC, Sokolova E, Darvishian F, Tsirigos A, Osman I, Hernando E | Sci Adv |
| Genome-wide analyses of histone modifications and chromatin accessibility reveal the distinct genomic compartments in the Irish potato famine pathogen Phytophthora infestans | Chen, H. et. al. | bioRxiv |
| AAV-mediated expression of secreted and transmembrane αKlotho isoforms rescues relevant aging hallmarks in senescent SAMP8 mice. | Roig-Soriano J, Griñán-Ferré C, Espinosa-Parrilla JF, Abraham CR, Bosch A, Pallàs M, Chillón M | Aging Cell |
| Neurogenesis in the neonatal rat hippocampus is regulated by sexually dimorphic epigenetic modifiers. | Stockman SL, Kight KE, Bowers JM, McCarthy MM | Biol Sex Differ |
| Iron nitrosyl complexes are formed from nitrite in the human placenta. | Mukosera GT, Principe P, Mata-Greenwood E, Liu T, Schroeder H, Parast M, Blood AB | J Biol Chem |
| Egr1 is a 3D matrix-specific mediator of mechanosensitive stem cell lineage commitment | Baek J, Lopez PA, Lee S, Kim TS, Kumar S, Schaffer DV | Sci Adv |
| Structure-activity relationship and antitumor activity of 1,4-pyrazine-containing inhibitors of histone acetyltransferases P300/CBP. | Nie S, Wu F, Wu J, Li X, Zhou C, Yao Y, Song Y | Eur J Med Chem |
| Deletion of ACLY Disrupts Histone Acetylation and IL-10 Secretion in Trophoblasts, Which Inhibits M2 Polarization of Macrophages: A Possible Role in Recurrent Spontaneous Abortion. | Chen X, Song QL, Li ZH, Ji R, Wang JY, Ge C, Xiao ZN, Guo DY, Yang J | Oxid Med Cell Longev |
| Trained Immunity Enhances Human Monocyte Function in Aging and Sepsis. | Gill PS, Ozment TR, Lewis NH, Sherwood ER, Williams DL | Front Immunol |
| Fatty acid tryptamide from cacao elongates Drosophila melanogaster lifespan with sirtuin-dependent heat shock protein expression. | Kanno K, Kayashima Y, Tamura K, Miyara T, Baba K, Koganei M, Natsume M, Imai S | Sci Rep |
| Single-cell sequencing reveals activation of core transcription factors in PRC2-deficient malignant peripheral nerve sheath tumor. | Zhang X, Lou HE, Gopalan V, Liu Z, Jafarah HM, Lei H, Jones P, Sayers CM, Yohe ME, Chittiboina P, Widemann BC, Thiele CJ, Kelly MC, Hannenhalli S, Shern JF | Cell Rep |
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