The ability to create defined mutations and to generate precise fusions of protein domams by modifications at the DNA level is now an accepted and routine technique in molecular biology This ability has developed over the past 10–l5 years and rests on a foundation of experiments on DNA.DNA hybridization that stretches back to the 1960s The 1993 Nobel lectures (1,2) provide a timely, historical survey of the development of key stages in the development of current methods.
