Antiepileptic drugs vary greatly in chemical structure. Analysis of these compounds by capillary electrophoresis (CE) requires different conditions for each one, or for each group. Acidic drugs can be analyzed easily by capillary zone electrophoresis in borate buffers (1 ); the neutral and the mixtures can be better analyzed by micellar electrokinetic chromatography (2 –4 ). Chapter 17 describes how phenobarbital and a few other antiepileptic drugs could be analyzed by CE.
