| Cells utilize RNA interference (RNAi) to regulate protein expression in many contexts. The discovery of RNAi has transformed our understanding of gene regulation as well as our ability to manipulate it. Gathered here is a selection of research and comment on RNAi published in the pages ofNature, including groundbreaking research from today"s issue. This focus also brings together news and reviews from across the Nature Publishing Group, and a fantastic animation offers the chance to view the RNAi process in action. |
RESEARCHTherapeutic silencing of an endogenous gene by systemic administration of modified siRNAs Soutschek J.et al.Nature432, 173 - 178 (11 Nov 2004) Processing of primary microRNAs by the Microprocessor complex Denli A.M.et al.Nature432, 231 - 235 (11 Nov 2004) The Microprocessor complex mediates the genesis of microRNAs Gregory R.I.et al.Nature432, 235 - 240 (11 Nov 2004) A pancreatic islet-specific microRNA regulates insulin secretion 226 Poy M.N.et al.Nature432, 226 - 230 (11 Nov 2004)NEWS AND VIEWSMedicine: A cholesterol connection in RNAi Rossi J.J.Nature432, 155 - 156 (11 Nov 2004)
INSIGHTNature Insight on RNA interference A collection of reviews exploring the ramifications and potential uses of RNAi.ARTICLESMicroRNAs act sequentially and asymmetrically to control chemosensory laterality in the nematode Chang S., Johnston R.J. Jr., Frokjaer-Jensen C., Lockery S. & Hobert O.Nature430, 785 - 789 (12 Aug 2004) Role of transposable elements in heterochromatin and epigenetic control Lippman Z.et al.Nature430, 471 - 476 (22 Jul 2004) Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain Ma J.B., Ye K. & Patel D.J.Nature429, 318 - 322 (20 May 2004) A large-scale RNAi screen in human cells identifies new components of the p53 pathway Berns K.et al.Nature428,431 - 437 (25 Mar 2004)
